OBJECTIVES: To review the characteristics and performance of research ethics committees in Spain in the evaluation of multicentre clinical trial drug protocols. DESIGN: A prospective study of 100 applications. SETTING: Forty-one committees reviewing clinical trial protocols, involving 50 hospitals in 25 cities. MAIN MEASURES: Protocol-related features, characteristics of research ethics committees and evaluation dynamics. RESULTS: The 100 applications involved 15 protocols (of which 12 were multinational) with 12 drugs. Committees met monthly (except one). They had a mean number of 12 (...) members, requested a mean of six complete dossiers and nine additional copies of the protocol with a mean deadline of 14 days before the meeting. All applications were approved except three (two of the three were open-label long-term safety trials rejected by the same committee), which were approved by the other committees involved. The mean time from submission to approval was 64 days. The mean time from submission to arrival of the approval document at our offices was 85 days. Twenty-five committees raised queries for 38 of the 97 finally approved applications. Impact of evaluation fee, number of members, queries raised and experience of committees on timings were not statistically significant. CONCLUSION: Obtaining ethical approval is time-consuming. There is much diversity in the research ethics committees' performance. A remarkable delay (> 20 days) exists between the decision and the arrival of the written approval, suggesting administrative or organisational problems. (shrink)

The following article is a response to the position paper of the Hastings Center, “Ethical Challenges of Chronic Illness”, a product of their three year project on Ethics and Chronic Care. The authors of this paper, three prominent bioethicists, Daniel Callahan, Arthur Caplan, and Bruce Jennings, argue that there should be a different ethic for acute and chronic care. In pressing this distinction they provide philosophical grounds for limiting medical care for the elderly and chronically ill. We give a critical (...) survey of their position and reject it as well as any attempt to characterize the physician-patient relationship as a commercial contract. We emphasize, as central features of good medical practice, a commitment to be the patient's agent and a determination to acquire and be guided by knowledge. These commitments may sometimes conflict with efforts to have the physician serve as an instrument of social and economic policies limiting medical care. (shrink)

Science and Religion: Methodology, History and Prospects in Latin America.

A partir del desafío que los ejemplos formulados por Gettier presentan a la habitual definición del conocimiento, se ofrece una comparación de la epistemología contemporánea con la teoría del conocimiento desarrollada por Polo. La crítica a la definición del conocimiento se articula en torno a la profundización en cada uno de los tres elementos que la componen y se muestra cómo pueden articularse internamente entre sí, profundizando en el valor ontológico del conocimiento, insistiendo en una comprensión más completa de la (...) verdad y su valor antropológico y avanzando en el valor científico de la justificación. (shrink)

From Analytic Philosophy to Theism: Antony Flew After the great idealistic systems, the advent of nihilism and the formulation of pragmatism, philosophy restarts again creatively. To understand this rise, I will argue about the essential relationship that philosophy should have with science. Then I will delineate, in line with Antony Flew’s history, the main philosophical arguments atheists present in analytic philosophy, and the characteristics that take the old arguments. Finally, I try to formulate as accurately as possible the main arguments (...) for the existence of God being discussed right now within the analytic tradition. (shrink)

The criticism of Bernstein on the encyclical Fides et ratio, claiming that it does not take into account the progress made by the best philosophies of this Century on the analysis of truth, is false. This paper show that the encyclical does take into account the achievements of analytical epistemology. Also it says that the even challenges analytical philosophy to deal with even more important issues such as the role of metaphysics in the analysis of human knowledge and conceptual language.

En la filosofía actual hay dos discusiones en curso en torno a la libertad: la contraposición entre compatibilismo e incompatibilismo y el sentido de la libertad, es decir de la subjetividad. He escogido el hilo conductor el concepto de posibilidad y el pensamiento de Harry Frankfurt para clarificar los puntos nodales de las discusiones y poder iluminarlos desde la antropología transcendental de Leonardo Polo para atenuar las contraposiciones y resolver las aporías a las que se enfrenta el pensamiento actual sobre (...) la libertad. (shrink)

Objectives: To review the performance of research ethics committees in Spain in assessing multicentre clinical trial drug protocols, and to evaluate if they would comply with the requirements of the new EU Directive to be implemented by May 2004.Design and setting: Prospective study of applications of MCT submitted to RECs.Main measurements: Protocol related features and evaluation process dynamics.Results: 187 applications to be performed in 114 centres, were reviewed by 62 RECs. RECs had a median number of 14 members, of which (...) three were lay members. All applications were approved except four which were however approved by the other RECs involved. The median times from submission to approval and from submission to reception at the sponsor’s offices were 48 and 62 days, respectively. In 55% of all applications approved, 41 RECs raised 307 queries, 40% of these were protocol related issues, and 38% related to the patients’ information sheets. RECs charging an evaluation fee in advance and applications with no queries raised were statistically significantly associated with shorter evaluation times. However, there is a gap of at least 1.5 weeks between the date of the meeting and the reception of the approval letter in the sponsor’s office.Conclusions: Evaluating MCT protocols by RECs is a time consuming process. Needing 1.5 weeks for communicating the decision taken by RECs to the sponsor suggests serious administrative shortcomings within most RECs. By significantly reducing the time for communication of their decisions, the majority of RECs would comply with the Directive requirement of a maximum 60 day period for the assessment of MCT. (shrink)

We consider the potential impact of Computer Supported Cooperative Work, with special reference to large technically advanced projects involving several organizations. It is vital that such projects are managed efficiently, without delays, since a product that reaches the market a few months earlier than its competitors enjoys a great advantage. Traditional methods of coordinating large projects, based on hierarchical communication, tend to produce delays, since technicians at remote sites are obliged to solve coordination problems by passing them up the hierachy. (...) It would be better if such problems were solved by improvising conferences among the technicians; Computer Supported Cooperative Work will provide the technical means of implementing this heterarchical style of management without losing control of the project. The use of computers as a social medium raises methodological and ethical issues which are discussed in the final section. (shrink)

Are we Human Beings Unable of God? José Cobo maintains that the worldview of contemporary man does not allow him to believe in the sense that the first Christians believed. And he argues that the main cause of that vision has been the development of empirical science. Here I argue that in reality the cause can best be described as an anthropological error, which carries with it a metaphysical deficit. On the other hand, we rectify certain intellectual resources with which (...) we intend to get out of this situation. (shrink)

Work on ethics, presented at a scientific conference held on May 23, 2014 in Ulaanbaatar.

The purpose of this study is to examine the relationship between contextual work-related factors on the one hand, in terms of job demands (i.e., risk factors) and job resources (i.e., protective factors), and work-family conflict in teachers on the other. Building on the Job Demands-Resources (JD-R) model, we hypothesized that job demands, namely qualitative and quantitative workload, are positively associated with work-family conflict in teachers. Moreover, in line with the buffer hypothesis of the JD-R, we expected job resources, in terms (...) of support from supervisor, job autonomy, and participation in decision making, to affect this association, which is expected to be stronger when job resources are low. The study was conducted in an Italian secondary school. Overall, 122 teachers completed a self-report questionnaire aimed at determining work-family conflict, as well as job demands and resources. The hypothesized relationships were tested using moderated multiple regression. The results of this study largely support our predictions. First, both aspects of workload were positively associated with work-family conflict. Secondly, job resources, including support from supervisor and participation in decision making, buffered this association, which was stronger when resources were low. On the contrary, job autonomy did not buffer the association between workload and work-family conflict. Overall, the results of this study are consistent with the Job Demands-Resources model and contribute to to the understanding of work–family conflict among teachers. More specifically, our study suggests that teachers with high levels of job resources, namely support from supervisor and participation in decision making, can effectively cope with job demands, in terms of both qualitative and quantitative workload, thus preventing negative consequences such as conflict between work and family domains. Interventions aimed at preventing work-family conflict among teachers should encourage organizations to optimize the balance between job demands and resources, as well as the identification and training of the workers at risk of work-family conflict. (shrink)

L’opera filosofica di Novalis, inedita e frammentaria per ragioni biografiche, è stata a lungo trascurata. Gli studi fichtiani e l’interesse per la scienza sono alla base della sua «Enciclopedistica», nella quale la filosofia della musica ha un posto rilevante. Novalis conosce la scienza acustica del suo tempo e riconduce i rapporti tra suoni e figure a una forza formatrice presente nella natura fin dal livello inorganico. La medesima forza si presenta poi nell’uomo tramite la voce, espressione più autentica della libertà (...) assoluta dell’Io. Lungi da ogni «sentimentalismo» l’identità di uomo e natura si manifesta in una rarefatta estetica simbolica condensata da Novalis nell’immagine dell’«arpa eolia». (shrink)

Il saggio è dedicato ad illustrare la figura di Riccardo Rufo di Cornovaglia del quale si conosce assai poco, soprattutto dal punto di vista biografico. Nella prima parte dello studio l'A., dopo aver tracciato brevemente un profilo della vita e delle opere dell'autore, passa a confutare tre posizioni storiografiche in base alle quali si afferma che 1) Rufo non era ancora maestro quando entrò nell'Ordine dei Minori 2) non avrebbe composto alcun commento alla Metafisica o ad alcuno dei libri naturales (...) di Aristotele 3) le sue lezioni su Aristotele non sarebbero state presentate a Parigi. È al secondo punto che l'A. ha dedicato più attenzione: Rufo infatti non solo sarebbe autore di un commento alla Metafisica che esercitò una notevole influenza su alcuni autori tra cui Ruggero Bacone, Roberto Grossatesta e Bonaventura da Bagnoregio. All'interno del dibattito de aeternitate Rufo fu fortemente influenzato dal Filopono: egli infatti fu il primo ad utilizzare gli argomenti contra basati sulla nozione di infinito, notoriamente ascritti a Bonaventura. Il suo intervento fu molto importante anche per quanto riguarda la dottrina dell'impetus e la discussione sui corpi celesti. (shrink)

Zájem současné sociologie a dalších společenských věd o výzkumy spokojenosti a štěstí zatemňuje skutečnost, že původně právě sociologie chtěla „štěstí" poskytovat a nahrazovat tak náboženské přístupy ke světu. Tento implicitně nábo- ženský charakter je patrný i v rané české sociologii v dílech prvních propagátorů sociologie, jako byl především Emanuel Makovička, a později u některých následovníků a epigonů T. G. Masaryka, v meziválečném období zejména u Ladislava Kunteho, R. I. Malého, Alexandra Sommera-Batěka, Jindřicha Fleischnera a Jana Duška. Z hlediska vývoje české (...) sociologie šlo o zcela okrajové postavy, ačkoli mnohé z nich vynikly v jiných oblastech, jako celek jsou nicméně vyjádřením jednoho z aspektů dobových teoretických úvah o společnosti, jejím uspořádání a vývoji, na který by nemělo být zapomínáno. Zatímco T. G. Masaryka a pozdější akademické sociology „omezoval" vědecký charakter jejich práce, a i pokud směřovali k sociálnímu reformismu, oddělovali jej od teoretické sociologie, „sociologie vedoucí ke štěstí" nalezla plné uplatnění ve vizích a ambiciózních projek- tech těchto amatérských takésociologů - třebaže skončily faktickými nezdary nebo ani nedošly praktického naplnění, ostatně stejně jako v případě jejich pravzoru, Comtova pozitivistického apoštolátu. (shrink)

Europa, cristianità, istruzione, educazione, società secolare, tempi moderni. Questi e molti altri ancora i temi che Rémi Brague affronta tin questo volume. Il continuo processo di individualizzazione, caratterizzato dal razionalismo, ha comportato un totale indebolimento dei legami societari e ha posto al centro le libertà e i diritti dei singoli. Si assiste così all’evoluzione di una società secolarizzata che giunta al suo capolinea non riesce più a bastare a se stessa. Il pensiero moderno non sembra essere in grado di giustificare (...) il fatto che esistono degli uomini sulla terra, cercando di costruire unicamente sul proprio terreno senza considerare ciò che trascende l’umano, Natura o Dio. “Il progetto dei Tempi moderni è fallito. L’ateismo è incapace di rispondere alla questione della legittimità dell’uomo”. Brague insiste nel mettere in rilievo il carattere missionario del cristianesimo: questo – scrive – non è riservato esclusivamente agli europei. Si chiede quindi Brague se la nostra società abbia ancora il desiderio di vivere e di agire e auspica che tale desiderio sia destato, attingendo alla sorgente della vita. Contro il cristianismo e l’umanismo si presenta come una originale riflessione sulla società di oggi, attenta a non nascondere l’aspirazione propria di ciascun individuo, per cui è legittimo parlare di ciò che veramente è ‘umano’ e di una dimensione spirituale che caratterizza ciascuna cultura. (shrink)